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KMID : 0369819970270010051
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Jorunal of Korean Pharmaceutical Sciences
1997 Volume.27 No. 1 p.51 ~ p.56
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Pharmacokinetic Interaction of Vancomycin and Probenecid in Rabbits
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이돈일/Lee DN
유재신/범진필/최준식/You JS/Burm JP/Choi JS
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Abstract
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This study was attempted to investigate the pharmacokinetic interaction of vancomycin (10 mg/kg, i.v.) and probenecid (7.5. 15, and 30 mg/kg, oral) in rabbits. The area under curve (AUC) of plasma vancomycin concentration was significantly increased (p<0.01) in rabbits when the probenecid was coadministrated. Volume of distribution (Vd) was significantly decreased (p<0.05) in rabbits coadministrated with probenecid (15 and 30 mg/kg) and total body clearance (CLt) was decreased significantly (p<0.05. p<0.01) in rabbits coadministrated with probenecid (7.5, 15 and 30 mg/kg). There was significant correlation between AUC and probenecid dose. From the results of this experiment, it is desirable to adjust dosage regimen of vancomycin for reduction of side or toxic effect when the probenecid is coadministered in clinical practice.
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KEYWORD
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Pharmacokinetics, Vancomycin, Probenecid, Interaction, Dosage regimem, Therapeutic drug monitoring
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